About Life Study

Neonatal HIV early infant diagnosis (EID) versus standard of care EID – Long term Impact on inFant hEalth: a feasibility study of point-of care testing at birth versus at 4-8 weeks of age, on the uptake of ART and infant prophylaxis, and on rates of infant survival, morbidity and retention in care.

 

The LIFE Study is a cluster randomised cohort study conducted at public health maternities in Tanzania (Mbeya and Songwe Regions) and Mozambique (Sofala and Manica Provinces) evaluating the clinical impact of infant birth point-of-care test & treat procedures in HIV-infected neonates.

 

  • Coordinator: Instituto Nacional de Saude (INS), Mozambique
  • Sponsor: Ludwig-Maximillians-Universität (LMU), Germany
  • Funder: European and Developing Countries Clinical Trials Partnership (EDCTP), UNITAID, Clinton Health Access Initiative (CHAI)
     

Anticipated impact

Identification of novel strategies using PoC-VL and enhanced PNP to further reduce MTCT
Demonstration that the UNAIDS 90:90:90 goals are achievable in infants by using PoC-EID linked to early ART and improved retention in care
Impact of PoC-EID linked and nurse initiated early infant ART on long-term infant mortality/morbidity
Cost effectiveness data on the impact of PoC-VL monitoring to reduce MTCT, and on the impact of PoCEID at birth and nurse initiated infant ART on long term HIV-infected infant health outcomes
Enhanced understanding of the impact of early and very early ART on viral reservoirs and HIV remission in infants.

 

Contact list

Positions

Contact Details

Overall Principal Investigator

Dr. Ilesh Jani, PhD

Instituto Nacional de Saude (INS)

Ministério da Saúde, Maputo, Mozambique

Sponsor Medical Expert & Protocol Chair

Dr. Arne Kroidl

Medical Centre of the University of Munich (LMU)

Division of Infectious Diseases and Tropical Medicine

Section International Medicine and Public Health

Principal Investigator Tanzania

Dr. Issa Sabi

NIMR- Mbeya Medical Research Centre (NIMR - MMRC)

Principal Investigator Portugal

Prof. Nuno Taveira

University of Lisbon

Instituto Universitário Egas Moniz (IUEM)

 

Ms. Lise Ellyin

Clinton Health Access Initiative Mozambique

Country Director